Operating to GMP & ICH Q7 standards across all manufacturing sites
Oligonucleotide Manufacturing

Oligonucleotides for next-generation modalities.

Therapeutic and diagnostic oligonucleotides produced with rigorous purification, advanced characterization, and complete traceability — from research quantities through GMP supply.

Overview

Built for emerging therapeutics.

We combine established phosphoramidite chemistry with deep modification know-how to deliver oligonucleotides that meet the exacting standards of modern modalities.

  • 01

    Proven Chemistries

    Phosphoramidite synthesis with modified backbones and sugars.

  • 02

    Modality Expertise

    Capability across antisense, siRNA, aptamers, and probes.

  • 03

    Research to GMP

    Phase-appropriate grades that scale with your program.

What We Offer

Services across the oligo lifecycle.

01

Synthesis Chemistries

Standard and modified backbones, sugars, and linkages for advanced sequences.

02

Modifications & Conjugation

5'/3' modifications, labels, GalNAc and other conjugation strategies.

03

Purification

Preparative chromatography delivering the purity profiles therapeutics demand.

04

Characterization

LC-MS, IEX, and orthogonal analytics for full identity and purity.

05

GMP Manufacturing

cGMP production with documentation ready for your filings.

06

Scale-Up

Robust, repeatable processes from milligram to commercial scale.

Applications

Where our oligos go to work.

Antisense (ASO)

Gapmers and steric blockers.

  • Modified backbones
  • Sugar modifications
  • Purity-critical release

siRNA

Duplex strategies.

  • Sense / antisense strands
  • Conjugation handles
  • Annealing & QC

Aptamers

Structured binders.

  • Selection support
  • Modified nucleotides
  • Fold-sensitive analytics

Primers & Probes

Diagnostics-grade.

  • Dye & quencher labeling
  • Tight specification
  • Documented lots
Why GBL

A partner you can build a pipeline on.

Reliable Partnership

Experienced specialists and a rigorous quality system stand behind every batch we deliver.

Tailored Service

Your priorities drive the process, supported by attentive, first-class technical service.

Innovation & Technology

An integrated approach to innovation that keeps your products and timelines dependable.

Excellence & Quality

From small-scale to large-volume, GMP or non-GMP, every project gets tailored analytics and oversight.

How It Works

From sequence to delivery.

Consult

A dedicated technical lead scopes your project, timeline, and regulatory needs.

Develop

Process and analytical development tuned for yield, purity, and scalability.

Manufacture

Production with in-process controls and full quality oversight.

Deliver

Validated global logistics get your product where it needs to be, on time.

Start Your Project

Tell us about your sequence.

Send your target and requirements and our team will respond with a quote within one business day.